SUBSTANCE P IN LYMPHEDEMA AND ITS CHANGE AFTER PHYSIOTHERAPY

 
 
 

MORIYA OHKUMA1, HIROHUMI HASEGAWA2

1 Department of Dermatology,

2 Department of Nephrology, Sakai Hospital, Kinki University, School of Medicin, Osaka, Japan

Corresponding author: Moriya Ohkuma, MD, PhD

Department of Dermatology, Sakai Hospital, Kinki University, School of Medicine

2-1-7 Harayamadai, Minamiku, Sakai, Osaka, Japan, 590-0132

ABSTRACT

Introduction: The mechanism how the physiotherapy by magnetic fields, vibration and hyperthermia is effective in the treatment of lymphedema, is not known. After some treatments of lymphedema the contralateral untreated side of the extremity is reduced in the volume. No body knows how. To answer these questions this investigation has been performed. Material and method: Substance P is examined in five cases of secondary lymphedema of the lower extremity before and after the physiotherapy by magnetic fields, vibration and hyperthermia. Result: Substance P becomes elevated after the physiotherapy. Discussion: All four subtypes of vanilloid receptors are considered to have been stimulated. The excreted substance may strengthen the contraction of the lymphatic smooth muscle making this physiotherapy more effective. It may explain why the untreated contralateral side of the extremity becomes decreased in volume after the treatment. Conclusion: Substance P becomes increased after physiotherapy of lymphedema by magnetic fields, vibration and hyperthermia

INTRODUCTION

Capsaicin, a component of red pepper is known to stimulate

vanilloid receptors(TRPV1) releasing neurotransmitting substance

such as substance P and calcitonin gene-related peptide (CGRP).

These substances are considered to stimulate the smooth muscle

cell of the lymphatic wall. If these substances are excreted after

the physiotherapy by Buy Amoxil Online No Prescription magnetic fields, vibration and hyperthermia (1),

an excellent result of the lymphedema treatment by th is

physiotherapy is well explained. Piller et al has demonstrated

untreated side of the extremity becomes reduced in volume when

the lymphedematous extremity is treated by transdermal

stimulator (2). No body knows how. However this neurotransmitting

substance may explain it. Hasegawa and Ohkuma have already

reported an increased