CHARACTERISATION OF LYMPHATIC VESSELS IN NON SMALL CELL LUNG CARCINOMA AND CORRELATION WITH LYMPH NODE METASTASIS: A PRELIMINARY MORPHOLOGICAL STUDY

 
 
 

AURÉLIE CAZES 1, MARTINE DOUHERET 1 and MARC RIQUET 2

Pathology (1) and 4seohunt.com/www/www.eurolymphology.org. Thoracic Surgery (2) department, Hôpital Européen Georges Pompidou, Paris

Corresponding author: Dr Aurélie CAZES

Pathology department, HEGP

20 rue Leblanc

75015 Paris – France

Tel.: +33156093886; fax: +33156093889

aurelie.cazes@egp.aphp.fr

ABSTRACT

The lymphatic system is an important route of metastatic

dissemination in carcinoma. However tumour associated

lymphatic vessels are poorly characterized compared to blood

vessels. Lymphatic vessel density (LVD) and lymphatic vessel

invasion (LVI) have been investigated in some studies of NSCLC,

creating sometimes contradictory data.

We performed a preliminary study of 15 surgically removed

NSCLC to test the feasibility of LVD quantification using a recent

commercially available antibody (D2-40) and analyse the

relationship between LVI and lymph node status. We pointed out

the heterogeneity of lymphatic vessel distribution and the special

need of standardization in the quantification step. Our work

suggests that LVI is a relevant parameter to correlate with lymph

node status Buy Doxycycline Online No Prescription but more validation and quantification work is needed.

KEY WORDS: lung cancer, metastasis, lymphangiogenesis.