THE ROLE OF DIAMAGNETIC PUMP (CTU mega 18) IN THE PHYSICAL TREATMENT OF LIMBS LYMPHOEDEMA. A CLINICAL STUDY

 
 
 

MARCELLO IZZO* **, LUIGI NAPOLITANO**, VINCENZO COSCIA ^ *, ANTONIO LA GATTA*, FABRIZIO MARIANI*, VINCENZO GASBARRO* °

* Research Centre “Mathematics for Technology”, VasaeTech workgroup.

^ Department of Mathematics, University of Ferrara.

° Department of Surgery, Anaesthesiology and Radiology, Vascular Surgery Unit,

University of Ferrara – Interuniversity Center of Study and Education in Phlebology.

** Oedema Center – Nola (NA).

INTRODUCTION

Lymphoedema represents a chronic pathology, that renders

patients physically and psychologically disabled, it is not easy to

control, and shows a marked tendency to spontaneously set in

complications. For such reasons lymphoedema demands for a

novel early, targeted and lasting diagnostic and therapeutic

approach (1).

So far it is frequently claimed, in a completely misleading manner,

that nor the lymphoedema physiopathology is clear or the

corresponding treatment is satisfactory. Nevertheless, though the

pathogenetic details are still an open question, the general

principles of the disease’s physiopathology are well known.

On one side, the main disorder may be characterized by a “low

output failure” of the lymphatic system, that is, a general

decreasing of the lymphatic flow. Such a disorder can be due to a

congenital lymphatic dysplasia (primary lymphoedema) or to an

anatomic obliteration, for example caused by a radical surgical

resection or by radiotherapy, or again as a consequence of repeated

lymphangitis with lymphangiosclerosis or, finally, produced by a

functional insufficiency such that due to lymphangiospasm,

paralysis and valvular insufficiency (secondary lymphoedema). In

any case, the common feature is a disorder in the lymphatic

transport mechanism, that decrease below the minimum capability

required by the microvascular filtrate, that includes plasmatic

proteins and cells that normally come out from the haematic

network entering the interstice.

On the other side, the “high output failure” of lymphatic

circulation occurs when an excess of capillary haematic filtrate

overcomes the normal transport capability of the lymphatic system

as for example happens in the liver cirrhosis (ascites), in the

nephrosic syndrome (anasarca) and in the inferior limbs deep

venous insufficiency (post-thrombophlebitic syndrome) and the

severe phlebostasis (2). The lymphatic injury, both moneygram charges for transfer primitive and

THE EUROPEAN JOURNAL

OF lymphology

and related problems

VOLUME 21 • No. 61 • 2010

INDEXED IN EXCERPTA MEDICA

THE ROLE OF DIAMAGNETIC PUMP (CTU mega 18)

IN THE PHYSICAL TREATMENT OF LIMBS LYMPHOEDEMA.

A CLINICAL STUDY

MARCELLO IZZO* **, LUIGI NAPOLITANO**, VINCENZO COSCIA ^ *, ANTONIO LA GATTA*,

FABRIZIO MARIANI*, VINCENZO GASBARRO* °

* Research Centre “Mathematics for Technology”, VasaeTech workgroup.

^ Department of Mathematics, University of Ferrara.

° Department of Surgery, Anaesthesiology and Radiology, Vascular Surgery Unit,

University of Ferrara – Interuniversity Center of Study and Education in Phlebology.

** Oedema Center – Nola (NA).

secondary, worsen in time due to the creation of a vicious circle:

LYMPHATIC DISORDER ? INCREASE OF PROTEIN RICH

INTERSTITIAL LIQUID ? DECREASE OF PROTEOLYTIC

CAPABILITY ? INCREASE OF INTERSTITIAL

CONNECTIVE ? FIBROSIS (3). In the subcutaneous tissue of

patients affected by lymphoedema an increase of the amount of

interstitial liquid, rich in proteins,is observed. To the increase a

chronic phlogosis is associated (the monocyte-macrophage system

and the fibroblast are activated), with a growth of the interstitial

matrix. The lymph accumulates in the fascia, forming “holes” or

“lymphatic lakes” and the three-dimensional retinaculum structure

addresses molecules and lymph toward the cutis surface. The

hydrophobic adipose lobules keep the water component off, so that

it accumulates along the retinaculum. Finally, we observe an

upsetting of the subcutaneous tissue, with the appearance of

“comb” picture (4).

PULSED LOW-FREQUENCY ELECTROMAGNETIC

FIELDS: The pulsed low-frequency (< 50 Hz) electromagnetic

fields (5) belong to he class of non ionizing radiations, that is, they

are characterized by an associated energy below 12 eV (electron-

Volt). Such an energy is insufficient both to turn on ionization

phenomena in molecules and to break even very weak chemical

bonds. For this reason in the last decades these radiations have not

been considered able to interact with biological systems and, as a

consequence, the studies on this subject were scarce and

information poor, especially when compared with the great

amount of knowledge concerning the interactions among ionizing

radiations and biological systems (6). Only recently, due to the

more and more common use of electromagnetic fields of different

intensity and frequencies (7), a vast research activity (8-9-10-11-12-13-14-15)

has started, addresses to the definition of their main biological and

therapeutic Buy Bactrim Online No Prescription effects, on which are based the exposition thresholds

currently recommended (Tab. 1):